Iron Accumulation Is Not Homogenous among Patients with Parkinson’s Disease

Iron Accumulation Is Not Homogenous among Patients with Parkinson's Disease

Background. Iron is considered to lead to neurodegeneration and has been hypothesized as a possible cause of Parkinson's disease (PD). Susceptibility-weighted imaging (SWI) is a powerful tool to measure phase related iron content of brain. Methods. Twelve de novo patients with PD were recruited from the Movement Disorders Clinic, Department of Neurology, Loma Linda University. Twelve age- and s...

Automatic, unsupervised classification of dyskinesia in patients with Parkinsons Disease

One of the characteristic symptoms of patients with Parkinson Disease (PD) is a rigidity of movement. These symptoms disappear after administration of Levodopa. However, the long-term use of levodopa causes involuntary movements (dyskinesia). A proper diagnosis requires an automatic, unsupervised method for the detection and classification of levodopa induced dyskinesia. The main problem, howev...

Evaluation of iron status in patients with coronary artery disease

Background: Iron can causes lipid peroxidation in vivo and in vitro. Iron  promotes myocardial injury in experimental animals. Low Density Lipoprotein (LDL) oxidation by oxidants including iron have a central role in atherosclerotic process. By this means, evaluation of serum iron in patients with coronary artery disease (CAD) has a significant importance. Materials and Methods: In this cross s...

The Rate of Iron Accumulation in Iron Storage Disease.

HFE genotype, parenchymal iron accumulation, and liver fibrosis in patients with nonalcoholic fatty liver disease.

BACKGROUND & AIMS Mutations in the hemochromatosis gene (HFE) (C282Y and H63D) lead to parenchymal iron accumulation, hemochromatosis, and liver damage. We investigated whether these factors also contribute to the progression of fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS We studied clinical, histologic (liver biopsy samples for hepatocellular iron accumulation...